Rh+/ RH-血型 基因型檢測;RhD抗原 基因型檢測
Rh+/ RH- 血型 基因型 檢測 ; RhD 抗原 基因型檢測
說明
懷孕過程
胎兒血型 若是 RH+ ( rs590787(T) )
媽媽血型 若是 RH - ( rs590787(C;C) )
懷孕過程 因某些原因(如胎盤組織輕微剝落)
使得胎兒血液 進入媽媽體內
胎兒RH+血液抗原(D antigen) 會使得媽媽製造RH+抗體 (D antibody)
該RH+抗體通過胎盤 會攻擊胎兒的紅血球 產生健康問題
嚴重導致胎兒或或新生兒死亡
# Rh (Rhesus) D antigen
# Rh+ 顯性
# Rh - 隱性
# Rh 不相容
血型RH+ 基因型 ( rs590787(T) ; rs590787(T/C) )
血型RH - 基因型 ( rs590787(C;C) )
Ref:
https://www.snpedia.com/index.php/Rs590787
rs590787 encodes a SNP that determines Rh (Rhesus) blood group (D antigen) status.
Someone who is "Rh positive" or "Rh+" has at least one + allele, i.e. rs590787(T),
but could have two. Someone who is "Rh negative" always has two - alleles and is rs590787(C;C). Wikipedia
Ref:
https://www.acog.org/womens-health/faqs/the-rh-factor-how-it-can-affect-your-pregnancy
How does a fetus get the Rh factor?
The Rh factor is inherited, meaning it is passed from parent to child through genes.
The fetus can inherit the Rh factor from the father or the mother.
Most people are Rh positive, meaning they have inherited the Rh factor from either their mother or father. If a fetus does not inherit the Rh factor from either the mother or father, then he or she is Rh negative. When a woman is Rh negative and her fetus is Rh positive, it is called Rh incompatibility.
Why is Rh incompatibility a problem?
When the blood of an Rh-positive fetus gets into the bloodstream of an Rh-negative woman,
her body will recognize that the Rh-positive blood is not hers.
Her body will try to destroy it by making anti-Rh antibodies.
These antibodies can cross the placenta and attack the fetus’s blood cells.
This can lead to serious health problems, even death, for a fetus or a newborn.